Life-course BMI and biomarkes in persons aged 60 years or older : a comparison of the USA and Costa Rica

Show simple item record Rehkopf, David H. Duong, Andrew Dow, William H. Rosero-Bixby, Luis 2018-11-28T20:29:21Z 2018-11-28T20:29:21Z 2018
dc.identifier.issn 1475-2727
dc.description.abstract Objective: There is a large literature linking current BMI to levels of cardiovascular risk biomarkers, but it is unknown whether measures of BMI earlier in the life course and maximum BMI are predictive of current levels of biomarkers. The objective of the current study was to determine how current, maximum and age-25 BMI among individuals over the age of 60 years are associated with their current levels of cardiovascular risk biomarkers. Design: Cross-sectional study with retrospective recall. Setting: Costa Rica (n 821) and the USA (n 4110). Subjects: Nationally representative samples of adults aged 60 years or over. Results: We used regression models to examine the relationship between multiple meaures of BMI with four established cardiovascular risk biomarkers. The most consistent predictor of current levels of systolic blood pressure, TAG and HDLcholesterol was current BMI. However, maximum BMI was the strongest predictor of glycosylated Hb (HbA1c) and was also related to HDL-cholesterol and TAG. HbA1c was independent of current BMI. We found that these relationships are consistent between Costa Rica and the USA for HbA1c and for HDL-cholesterol. Conclusions: Current levels of cardiovascular risk biomarkers are not only the product of current levels of BMI, but also of maximum lifetime BMI, particularly for levels of HbA1c and for HDL-cholesterol. Managing maximum obtained BMI over the life course may be most critical for maintaining the healthiest levels of cardiovascular risk. en
dc.language.iso en en
dc.publisher Cambridge University Press en
dc.rights Atribución-NoComercial-SinDerivadas 3.0 Costa Rica *
dc.rights.uri *
dc.subject Biomarcadores es
dc.subject Ciclo de vida es
dc.subject Adulto mayor es
dc.title Life-course BMI and biomarkes in persons aged 60 years or older : a comparison of the USA and Costa Rica en
dc.title.alternative Public Health Nutrition. doi:10.1017/S1368980018002276 en
dc.type Article en

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Atribución-NoComercial-SinDerivadas 3.0 Costa Rica Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Costa Rica

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