Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region

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dc.contributor.author McEwen, Lisa M.
dc.contributor.author Morin, Alexander M.
dc.contributor.author Rachel D., Edgar
dc.contributor.author Maclsaac, Julia L.
dc.contributor.author Jones, Meaghan J.
dc.contributor.author Dow, William H.
dc.contributor.author Rosero-Bixby, Luis
dc.contributor.author Kobor, Michael S.
dc.contributor.author Rehkop, David H.
dc.date.accessioned 2018-01-17T21:54:51Z
dc.date.available 2018-01-17T21:54:51Z
dc.date.issued 2017
dc.identifier.issn 1756-8935
dc.identifier.uri http://biblioteca.ccp.ucr.ac.cr/handle/123456789/1596
dc.description.abstract The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population’s unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. es_ES
dc.language.iso en es_ES
dc.publisher BMC es_ES
dc.rights Atribución-NoComercial-SinDerivadas 3.0 Costa Rica *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cr/ *
dc.subject Metilación del ADN es_ES
dc.subject Longevidad es_ES
dc.subject Biodemografía es_ES
dc.title Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region es_ES
dc.title.alternative Epigenetics & Chromatin, 10(1), 21. DOI: 10.1186/s13072-017-0128-2. es_ES
dc.type Article es_ES


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