Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region

dc.contributor.author	McEwen, Lisa M.
dc.contributor.author	Morin, Alexander M.
dc.contributor.author	Rachel D., Edgar
dc.contributor.author	Maclsaac, Julia L.
dc.contributor.author	Jones, Meaghan J.
dc.contributor.author	Dow, William H.
dc.contributor.author	Rosero-Bixby, Luis
dc.contributor.author	Kobor, Michael S.
dc.contributor.author	Rehkop, David H.
dc.date.accessioned	2018-01-17T21:54:51Z
dc.date.available	2018-01-17T21:54:51Z
dc.date.issued	2017
dc.identifier.issn	1756-8935
dc.identifier.uri	http://biblioteca.ccp.ucr.ac.cr/handle/123456789/1596
dc.description.abstract	The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population’s unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts.	en
dc.language.iso	en	en
dc.publisher	BMC	en
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Costa Rica	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cr/	*
dc.subject	Metilación del ADN	es
dc.subject	Longevidad	es
dc.subject	Biodemografía	es
dc.title	Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region	en
dc.title.alternative	Epigenetics & Chromatin, 10(1), 21. DOI: 10.1186/s13072-017-0128-2.	en
dc.type	Article	en