Genetic variants of the lipoprotein lipase gene and myocardial infarction in the central valle of Costa Rica

Show simple item record Yang, Yadong Ruiz Narváez, Edward A. Niu, Tianhua Xu, Xiping Campos, Hannia 2016-08-23T15:05:39Z 2016-08-23T15:05:39Z 2004
dc.identifier.issn 1539-7262
dc.description.abstract To assess common variants of the LPL gene that could influence susceptibility to myocardial infarction (MI), we assessed three functional single-nucleotide polymorphisms (SNPs), D9N, N291S, and S447X, in 1,321 survivors of a first acute MI and 1,321 population-based controls, matched for age, gender, and area of residence, all living in the Central Valley of Costa Rica. Conditional logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI). The frequency of the X447 mutant allele was significantly lower in cases than in controls (6.2% vs. 7.6%; P<0.01), whereas no association with MI was found for D9N or N291S. The OR (95% CI) for carriers vs. noncarriers of the X447 allele was 0.80 (0.63–1.01); when considering the haplotype that contained X447 and normal alleles of D9N and N291S, the OR (95% CI) was 0.66 (0.48–0.91). Twelve other SNPs were assessed in a subgroup of the population, of which the four functional SNPs were found to be monomorphic, and no correlation with MI was observed for the other eight neutral SNPs. The X447 mutant allele of the LPL gene may protect from MI risk, although this effect is small. en
dc.language.iso en en
dc.publisher American Society for Biochemistry and Molecular Biology en
dc.rights Atribución-NoComercial-CompartirIgual 3.0 Costa Rica *
dc.rights.uri *
dc.subject Lipoproteina lipasa es
dc.subject Enfermedades cardiovasculares es
dc.title Genetic variants of the lipoprotein lipase gene and myocardial infarction in the central valle of Costa Rica en
dc.title.alternative Journal of Lipid Research, 45(11) en
dc.type Article en

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