Effect of apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica

Abstract

Apolipoprotein E (apoE) is a ligand for the low-density lipoprotein (LDL) receptor and the LDL receptor-related protein (LRP) (Mahley and Rall 2000). Through these receptors apoE mediates the uptake of chylomicron remnants into the liver and the uptake of circulating very low density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) particles into peripheral tissues and cells (Mahley and Rall 2000).